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TargetMacrophage metalloelastase
LigandBDBM28481
Substrate/CompetitorBDBM28488
Meas. Tech.MMP Inhibition Assay
pH7.5±n/a
Temperature295.15±n/a K
IC50 1.1±n/a nM
Citation Li, WLi, JWu, YWu, JHotchandani, RCunningham, KMcFadyen, IBard, JMorgan, PSchlerman, FXu, XTam, SGoldman, SJWilliams, CSypek, JMansour, TS A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408). J Med Chem52:1799-802 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Macrophage metalloelastase
Name:Macrophage metalloelastase
Synonyms:HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:Enzyme
Mol. Mass.:54012.99
Organism:Homo sapiens (Human)
Description:P39900
Residue:470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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  Blast E-value cutoff:
BDBM28481
BDBM28488
NameBDBM28481
Synonyms:(2S)-3-methyl-2-{[12-({[2-(thiophen-2-yl)ethyl]carbamoyl}amino)-8-oxatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaene-5-]sulfonamido}butanoic acid | dibenzofuran (DBF) scaffold, (S)-26
TypeSmall organic molecule
Emp. Form.C24H25N3O6S2
Mol. Mass.515.602
SMILESCC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)NCCc3cccs3)cc21)C(O)=O |r|
Structure
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