Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM28590 |
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Substrate/Competitor | BDBM21342 |
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Meas. Tech. | Filtration Binding Assay |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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Ki | 61.6±n/a nM |
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Citation | Singer, JM; Wilson, MW; Johnson, PD; Graham, SR; Cooke, LW; Roof, RL; Boxer, PA; Gold, LH; Meltzer, LT; Janssen, A; Roush, N; Campbell, JE; Su, TZ; Hurst, SI; Stoner, CL; Schwarz, JB Synthesis and SAR of tolylamine 5-HT6 antagonists. Bioorg Med Chem Lett19:2409-12 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM28590 |
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BDBM21342 |
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Name | BDBM28590 |
Synonyms: | 1-{3-[(3,4-dichlorophenyl)methoxy]-2-methylphenyl}piperazine | tolylpiperazine, 5f |
Type | Small organic molecule |
Emp. Form. | C18H20Cl2N2O |
Mol. Mass. | 351.27 |
SMILES | Cc1c(OCc2ccc(Cl)c(Cl)c2)cccc1N1CCNCC1 |
Structure |
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