| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 6 |
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| Ligand | BDBM28593 |
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| Substrate/Competitor | BDBM21342 |
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| Meas. Tech. | Filtration Binding Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 70.7±n/a nM |
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| Citation |  Singer, JM; Wilson, MW; Johnson, PD; Graham, SR; Cooke, LW; Roof, RL; Boxer, PA; Gold, LH; Meltzer, LT; Janssen, A; Roush, N; Campbell, JE; Su, TZ; Hurst, SI; Stoner, CL; Schwarz, JB Synthesis and SAR of tolylamine 5-HT6 antagonists. Bioorg Med Chem Lett19:2409-12 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| 5-hydroxytryptamine receptor 6 |
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| Name: | 5-hydroxytryptamine receptor 6 |
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| Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46968.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50406 |
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| Residue: | 440 |
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| Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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| BDBM28593 |
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| BDBM21342 |
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| Name | BDBM28593 |
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| Synonyms: | 1-{2-methyl-3-[(1R)-1-phenylethoxy]phenyl}piperazine | tolylpiperazine, 5j |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24N2O |
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| Mol. Mass. | 296.4067 |
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| SMILES | C[C@@H](Oc1cccc(N2CCNCC2)c1C)c1ccccc1 |r| |
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| Structure | 
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