Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
Target5-hydroxytryptamine receptor 6
LigandBDBM28597
Substrate/CompetitorBDBM21342
Meas. Tech.Filtration Binding Assay
pH7.5±n/a
Temperature295.15±n/a K
Ki 92.5±n/a nM
Citation Singer, JMWilson, MWJohnson, PDGraham, SRCooke, LWRoof, RLBoxer, PAGold, LHMeltzer, LTJanssen, ARoush, NCampbell, JESu, TZHurst, SIStoner, CLSchwarz, JB Synthesis and SAR of tolylamine 5-HT6 antagonists. Bioorg Med Chem Lett19:2409-12 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
5-hydroxytryptamine receptor 6
Name:5-hydroxytryptamine receptor 6
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46968.43
Organism:Homo sapiens (Human)
Description:P50406
Residue:440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM28597
BDBM21342
NameBDBM28597
Synonyms:4-{2-methyl-3-[(3-methylphenyl)methoxy]phenyl}piperidine | tolylpiperidine, 9d
TypeSmall organic molecule
Emp. Form.C20H25NO
Mol. Mass.295.4186
SMILESCc1cccc(COc2cccc(C3CCNCC3)c2C)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: