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Target5-Hydroxytryptamine receptor 6 (5-HT6)
LigandBDBM28603
Substrate/CompetitorBDBM21342
Meas. Tech.Filtration Binding Assay
pH7.5±n/a
Temperature295.15±n/a K
Ki 2.8±n/a nM
Citation Singer JMWilson MWJohnson PDGraham SRCooke LWRoof RLBoxer PAGold LHMeltzer LTJanssen ARoush NCampbell JESu TZHurst SIStoner CLSchwarz JB Synthesis and SAR of tolylamine 5-HT6 antagonists. Bioorg Med Chem Lett 19:2409-12 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
5-Hydroxytryptamine receptor 6 (5-HT6)
Name:Serotonin (5-HT) receptor
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46968.43
Organism:Homo sapiens (Human)
Description:Cultured Hela cells expressing h5-HT6 receptors.
Residue:440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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  Blast E-value cutoff:
BDBM28603
BDBM21342
NameBDBM28603
Synonyms:4-{3-[(1S)-1-(3-chlorophenyl)ethoxy]-2-methylphenyl}piperidine | tolylpiperidine, 9k
TypeSmall organic molecule
Emp. Form.C20H24ClNO
Mol. Mass.329.864
SMILESC[C@H](Oc1cccc(C2CCNCC2)c1C)c1cccc(Cl)c1 |r|
Structure
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