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Target5-Hydroxytryptamine receptor 6 (5-HT6)
LigandBDBM28614
Substrate/CompetitorBDBM21342
Meas. Tech.Filtration Binding Assay
Temperature298.15±n/a K
Ki 239±n/a nM
Commentsextracted
Citation Singer JMWilson MWJohnson PDGraham SRCooke LWRoof RLBoxer PAGold LHMeltzer LTJanssen ARoush NCampbell JESu TZHurst SIStoner CLSchwarz JB Synthesis and SAR of tolylamine 5-HT6 antagonists. Bioorg Med Chem Lett 19:2409-12 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
5-Hydroxytryptamine receptor 6 (5-HT6)
Name:Serotonin (5-HT) receptor
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46968.43
Organism:Homo sapiens (Human)
Description:Cultured Hela cells expressing h5-HT6 receptors.
Residue:440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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  Blast E-value cutoff:
BDBM28614
BDBM21342
NameBDBM28614
Synonyms:2-[(2,4-difluorophenyl)methoxy]-3-methyl-4-(piperidin-4-yl)pyridine | pyridylpiperidine, 13h
TypeSmall organic molecule
Emp. Form.C18H20F2N2O
Mol. Mass.318.361
SMILESCc1c(OCc2ccc(F)cc2F)nccc1C1CCNCC1
Structure
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