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Target5-hydroxytryptamine receptor 6
LigandBDBM28624
Substrate/CompetitorBDBM21342
Meas. Tech.Filtration Binding Assay
Temperature298.15±n/a K
Ki 6.5±n/a nM
Commentsextracted
Citation Singer, JMWilson, MWJohnson, PDGraham, SRCooke, LWRoof, RLBoxer, PAGold, LHMeltzer, LTJanssen, ARoush, NCampbell, JESu, TZHurst, SIStoner, CLSchwarz, JB Synthesis and SAR of tolylamine 5-HT6 antagonists. Bioorg Med Chem Lett19:2409-12 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
5-hydroxytryptamine receptor 6
Name:5-hydroxytryptamine receptor 6
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46968.43
Organism:Homo sapiens (Human)
Description:P50406
Residue:440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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  Blast E-value cutoff:
BDBM28624
BDBM21342
NameBDBM28624
Synonyms:4-[3-(3-fluorophenoxymethyl)-2-methylphenyl]piperidine | tolylpiperidine, 17b
TypeSmall organic molecule
Emp. Form.C19H22FNO
Mol. Mass.299.3825
SMILESCc1c(COc2cccc(F)c2)cccc1C1CCNCC1
Structure
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