| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor delta |
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| Ligand | BDBM28693 |
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| Substrate/Competitor | BDBM28662 |
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| Meas. Tech. | Radioligand Binding Assay (IC50) and Cell-Based Transcription Assay (EC50) |
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| IC50 | 50±n/a nM |
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| EC50 | 631±n/a nM |
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| Citation |  Shearer, BG; Patel, HS; Billin, AN; Way, JM; Winegar, DA; Lambert, MH; Xu, RX; Leesnitzer, LM; Merrihew, RV; Huet, S; Willson, TM Discovery of a novel class of PPARdelta partial agonists. Bioorg Med Chem Lett18:5018-22 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Peroxisome proliferator-activated receptor delta |
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| Name: | Peroxisome proliferator-activated receptor delta |
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| Synonyms: | NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta |
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| Type: | Enzyme |
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| Mol. Mass.: | 49910.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q03181 |
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| Residue: | 441 |
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| Sequence: | MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
KKTETETSLHPLLQEIYKDMY
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| BDBM28693 |
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| BDBM28662 |
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| Name | BDBM28693 |
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| Synonyms: | 2-({3-[(7-methoxy-1H-indole-1-)sulfonyl]benzene}amido)-5-methylbenzoic acid | Anthranilic acid deriv., 31 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H20N2O6S |
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| Mol. Mass. | 464.49 |
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| SMILES | COc1cccc2ccn(c12)S(=O)(=O)c1cccc(c1)C(=O)Nc1ccc(C)cc1C(O)=O |
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| Structure | 
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