Reaction Details |
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Target | Receptor-interacting serine/threonine-protein kinase 3 |
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Ligand | BDBM392806 |
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Substrate/Competitor | n/a |
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Meas. Tech. | RIPK3 HTRF Kinase Assay |
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IC50 | <30±n/a nM |
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Citation | Hart, AC; Pitts, WJ; Mastalerz, H; Guo, J; Brown, GD Substituted dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones as RIPK3 inhibitors US Patent US10301306 Publication Date 5/28/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Receptor-interacting serine/threonine-protein kinase 3 |
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Name: | Receptor-interacting serine/threonine-protein kinase 3 |
Synonyms: | RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3 |
Type: | PROTEIN |
Mol. Mass.: | 56886.12 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_881455 |
Residue: | 518 |
Sequence: | MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE
VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL
LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG
GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP
SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST
VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS
VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG
PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA
PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
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BDBM392806 |
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n/a |
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Name | BDBM392806 |
Synonyms: | N-(4-(3-(4-Fluorophenyl)-1-(4-methylbenzyl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl)pyridin-2-yl)acetamide | US10301306, Example 4 |
Type | Small organic molecule |
Emp. Form. | C28H25FN4O2 |
Mol. Mass. | 468.5221 |
SMILES | CC(=O)Nc1cc(ccn1)-c1c(c2c(CCNC2=O)n1Cc1ccc(C)cc1)-c1ccc(F)cc1 |
Structure |
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