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TargetReceptor-interacting serine/threonine-protein kinase 3
LigandBDBM392985
Substrate/Competitorn/a
Meas. Tech.RIPK3 HTRF Kinase Assay
IC50<30±n/a nM
Citation Hart ACPitts WJMastalerz HGuo JBrown GD Substituted dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones as RIPK3 inhibitors US Patent  US10301306 Publication Date 5/28/2019  Article
More Info.:Get all data from this article,  Assay Method
 
Receptor-interacting serine/threonine-protein kinase 3
Name:Receptor-interacting serine/threonine-protein kinase 3
Synonyms:RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | Receptor-interacting protein 3
Type:PROTEIN
Mol. Mass.:56886.12
Organism:Homo sapiens (Human)
Description:ChEMBL_881455
Residue:518
Sequence:
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE
VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL
LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG
GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP
SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST
VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS
VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG
PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA
PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM392985
n/a
NameBDBM392985
Synonyms:US10301306, Example 183
TypeSmall organic molecule
Emp. Form.C25H24FN5O2
Mol. Mass.445.4888
SMILESCOc1cnccc1-c1c(c2c(CCNC2=O)n1Cc1cc(C)nn1C)-c1ccc(F)cc1 |(-2.87,-4.05,;-2.1,-2.72,;-2.87,-1.39,;-4.41,-1.39,;-5.18,-.05,;-4.41,1.28,;-2.87,1.28,;-2.1,-.05,;-.56,-.05,;.34,1.19,;1.81,.72,;1.81,-.82,;3.14,-1.59,;4.47,-.82,;4.47,.72,;3.14,1.49,;3.14,3.03,;.34,-1.3,;-.06,-2.79,;1.03,-3.88,;2.56,-3.71,;3.19,-5.12,;4.7,-5.44,;2.05,-6.15,;.71,-5.38,;-.69,-6.01,;-.06,2.68,;1.03,3.77,;.63,5.26,;-.85,5.66,;-1.25,7.14,;-1.94,4.57,;-1.54,3.08,)|
Structure
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