| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor delta |
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| Ligand | BDBM28769 |
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| Substrate/Competitor | BDBM10852 |
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| Meas. Tech. | Cell-Based Transcription Assay |
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| EC50 | 70±n/a nM |
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| Comments | 83% efficacy. |
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| Citation |  Epple, R; Azimioara, M; Russo, R; Xie, Y; Wang, X; Cow, C; Wityak, J; Karanewsky, D; Bursulaya, B; Kreusch, A; Tuntland, T; Gerken, A; Iskandar, M; Saez, E; Martin Seidel, H; Tian, SS 3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists. Part 2. Bioorg Med Chem Lett16:5488-92 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Peroxisome proliferator-activated receptor delta |
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| Name: | Peroxisome proliferator-activated receptor delta |
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| Synonyms: | NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta |
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| Type: | Enzyme |
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| Mol. Mass.: | 49910.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q03181 |
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| Residue: | 441 |
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| Sequence: | MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
KKTETETSLHPLLQEIYKDMY
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| BDBM28769 |
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| BDBM10852 |
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| Name | BDBM28769 |
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| Synonyms: | 2-[3-(4-{[2-(2,4-dichlorophenoxy)ethyl]carbamoyl}-5-phenyl-1,2-oxazol-3-yl)phenyl]acetic acid | trisubstituted isoxazole, 17d |
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| Type | Small organic molecule |
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| Emp. Form. | C26H20Cl2N2O5 |
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| Mol. Mass. | 511.353 |
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| SMILES | OC(=O)Cc1cccc(c1)-c1noc(c1C(=O)NCCOc1ccc(Cl)cc1Cl)-c1ccccc1 |
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| Structure | 
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