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TargetHIV-1 Protease
LigandBDBM430
Substrate/CompetitorPeptide substrate
Meas. Tech.Protease Inhibition Assay
Ki 0.03±n/a nM
Citation Boyer FEVara Prasad JVDomagala JMEllsworth ELGajda CHagen SEMarkoski LJTait BDLunney EAPalovsky AFerguson DGraham NHoller THupe DNouhan CTummino PJUrumov AZeikus EZeikus GGracheck SJSanders JMVanderRoest SBrodfuehrer JIyer KSinz MGulnik SV 5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: potent nonpeptidic inhibitors of HIV protease. J Med Chem 43:843-58 (2000) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
HIV-1 Protease
Name:HIV-1 Protease
Synonyms:n/a
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:HIV-1 Protease chain A
Synonyms:HIV protease
Type:Enzyme Subunit
Mol. Mass.:358.43
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:3
Sequence:
n/a
 
Component 2
Name:HIV-1 Protease chain B
Synonyms:n/a
Type:Enzyme Subunit
Mol. Mass.:358.43
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:3
Sequence:
n/a
 
BDBM430
Peptide substrate
Name:Peptide substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:3763.66
Organism:n/a
Description:n/a
Residue:35
Sequence:
His-Lys-Ala-Arg-Val-Leu-(p-NO2-Phe)-Glu-Ala-Nle-Ser-NH2