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TargetDihydroorotate dehydrogenase (quinone), mitochondrial
LigandBDBM28843
Substrate/CompetitorBDBM14700
Meas. Tech.DHODH Inhibition Assay
IC50 77±n/a nM
Citation Gujjar, RMarwaha, AEl Mazouni, FWhite, JWhite, KLCreason, SShackleford, DMBaldwin, JCharman, WNBuckner, FSCharman, SRathod, PKPhillips, MA Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J Med Chem52:1864-72 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Dihydroorotate dehydrogenase (quinone), mitochondrial
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | PYRD_PLAF7
Type:Enzyme
Mol. Mass.:65581.88
Organism:Plasmodium falciparum (isolate 3D7)
Description:Q08210
Residue:569
Sequence:
MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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  Blast E-value cutoff:
BDBM28843
BDBM14700
NameBDBM28843
Synonyms:N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | triazolopyrimidine-based compound, DSM125
TypeSmall organic molecule
Emp. Form.C13H9F4N5
Mol. Mass.311.2377
SMILESCc1cc(Nc2ccc(c(F)c2)C(F)(F)F)n2ncnc2n1
Structure
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