Ki Summary

Reaction Details

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Target

Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517]

Ligand

BDBM28843

Substrate/Competitor

BDBM14700

Meas. Tech.

DHODH Inhibition Assay

IC50

260±n/a nM

Citation

Gujjar, R; Marwaha, A; El Mazouni, F; White, J; White, KL; Creason, S; Shackleford, DM; Baldwin, J; Charman, WN; Buckner, FS; Charman, S; Rathod, PK; Phillips, MA Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J Med Chem52:1864-72 (2009) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517]

Name:

Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517]

Synonyms:

Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial, putative

Type:

Enzyme

Mol. Mass.:

47311.25

Organism:

Plasmodium berghei

Description:

A0A509AEH5[100-517]

Residue:

418

Sequence:

MKRFDERMNKEKSKHKKVLFFIFSSIVGLYMYFESYNPEFFMYDVFLDFCLNYVDSEVCH
DLFLLLGKYGLLPYDTSNDSVYATSDIKNLNFINPFGVAAGFDKNGICIDSILKLGFSFI
EIGTITPKPQKGNNKPRIFRDVENKSIINACGFNNIGCDKVTENLINFRKKQEEDKLLSK
HIVGVSIGKNKHTENIVDDLKYSIYKIARYADYIAINVSSPNTPGLRDNQESNKLKNIIL
FVKQEINKIEQIGHNGETFWMNTIKKKPLVFVKLAPDLENSEKKKIAQVLLDTGIDGMII
SNTTINKMDIKSFEDKKGGVSGKKLKDLSTNLISDMYIYTNKQIPIIASGGILTGADALE
KIEAGASVCQLYSCLVFNGVKSAIQIKREFNNALYQKGYYNLREAIGKKHSNAKSLKV

BDBM28843

BDBM14700

Name

BDBM28843

Synonyms:

N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | triazolopyrimidine-based compound, DSM125

Type

Small organic molecule

Emp. Form.

C13H9F4N5

Mol. Mass.

311.2377

SMILES

Cc1cc(Nc2ccc(c(F)c2)C(F)(F)F)n2ncnc2n1

Structure