| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
|---|
| Ligand | BDBM393431 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assay |
|---|
| Ki | 0.006±n/a nM |
|---|
| Citation |  Burch, J; Chen, H; Wang, X Oxepan-2-yl-pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent US9963446 Publication Date 5/8/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase pim-1 |
|---|
| Name: | Serine/threonine-protein kinase pim-1 |
|---|
| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 35681.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11309 |
|---|
| Residue: | 313 |
|---|
| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
|
|
|
|---|
| BDBM393431 |
|---|
| n/a |
|---|
| Name | BDBM393431 |
|---|
| Synonyms: | N-(5-((2S,5R,6S,7R)-5-amino-6- methoxy-7-methyloxepan-2-yl)- 1-methyl-1H-pyrazol-4-yl)-2- (2,6-difluorophenyl)thiazole-4- carboxamide | US9963446, Example 118 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25F2N5O3S |
|---|
| Mol. Mass. | 477.527 |
|---|
| SMILES | CO[C@H]1[C@H](N)CC[C@H](O[C@@H]1C)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
