| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM393434 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| Ki | 0.005±n/a nM |
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| Citation |  Burch, J; Chen, H; Wang, X Oxepan-2-yl-pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent US9963446 Publication Date 5/8/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM393434 |
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| n/a |
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| Name | BDBM393434 |
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| Synonyms: | N-(5-((2S,5R,6R,7S)-5-amino-6- fluoro-7-methyloxepan-2-yl)-1- methyl-1H-pyrazol-4-yl)-2-(2,6- difluorophenyl)thiazole-4- carboxamide | US9963446, Example 121 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22F3N5O2S |
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| Mol. Mass. | 465.492 |
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| SMILES | C[C@@H]1O[C@@H](CC[C@@H](N)[C@H]1F)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C |r| |
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| Structure | 
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