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TargetBotulinum neurotoxin type A2 [1-425]
LigandBDBM28913
Substrate/CompetitorSNAP-25-based peptide substrate
Meas. Tech.In Vitro Assessment of Peptide Substrate Cleavage by BoNTA-LC
pH7.4±n/a
Temperature295.15±n/a K
IC50 2900±400 nM
Citation Moe, STThompson, ABSmith, GMFredenburg, RAStein, RLJacobson, AR Botulinum neurotoxin serotype A inhibitors: small-molecule mercaptoacetamide analogs. Bioorg Med Chem17:3072-9 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Botulinum neurotoxin type A2 [1-425]
Name:Botulinum neurotoxin type A2 [1-425]
Synonyms:BXA2_CLOBJ | BoNT/A LC | Botulinum Neurotoxin Type A | Botulinum neurotoxin A light chain | atx | bna | bonT | bont/a2 | botA
Type:Metalloprotease
Mol. Mass.:48687.43
Organism:Clostridium botulinum
Description:Recombinant C. botulinum LC/A (1-425) was expressed in E. coli.
Residue:425
Sequence:
MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLN
PPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGG
STIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGY
GSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPN
RVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKA
KSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKV
INRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLKNFT
GLFEF
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  Blast E-value cutoff:
BDBM28913
SNAP-25-based peptide substrate
Name:SNAP-25-based peptide substrate
Synonyms:n/a
Type:Fluorescent peptide
Mol. Mass.:3503.44
Organism:n/a
Description:n/a
Residue:29
Sequence:
SNRTRIDEAN[2,4-dinitrophenyl-K]RACRML