| Reaction Details |
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 | Report a problem with these data |
| Target | Gastric inhibitory polypeptide receptor |
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| Ligand | BDBM29132 |
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| Substrate/Competitor | 125I-GIP |
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| Meas. Tech. | SPA Receptor Binding Assay |
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| IC50 | 316±n/a nM |
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| Citation |  Madsen, P; Kodra, JT; Behrens, C; Nishimura, E; Jeppesen, CB; Pridal, L; Andersen, B; Knudsen, LB; Valcarce-Aspegren, C; Guldbrandt, M; Christensen, IT; Jørgensen, AS; Ynddal, L; Brand, CL; Bagger, MA; Lau, J Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties. J Med Chem52:2989-3000 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Gastric inhibitory polypeptide receptor |
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| Name: | Gastric inhibitory polypeptide receptor |
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| Synonyms: | GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53173.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1518286 |
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| Residue: | 466 |
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| Sequence: | MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA
CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN
PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF
MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY
LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR
TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV
TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ
RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
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| BDBM29132 |
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| 125I-GIP |
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| Name: | 125I-GIP |
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| Synonyms: | 125I-Gastric inhibitory polypeptide | 125I-Glucose-dependent insulinotropic polypeptide |
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| Type: | radiolabeled peptide substrate |
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| Mol. Mass.: | 4977.06 |
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| Organism: | Sus scrofa (Pig) |
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| Description: | n/a |
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| Residue: | 42 |
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| Sequence: | YAEGTFISDYSIAMDKIRQQDFVNWLLAQKGKKSDWKHNITQ
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