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TargetCorticotropin-releasing factor receptor 1
LigandBDBM29474
Substrate/Competitor125I-Tyr(0)-ovine-CRF
Meas. Tech.In Vitro Binding Autoradiography
Temperature298.15±n/a K
IC50 38.56±n/a nM
Commentsextracted
Citation Gilligan, PJHe, LClarke, TTivitmahaisoon, PLelas, SLi, YWHeman, KFitzgerald, LMiller, KZhang, GMarshall, AKrause, CMcElroy, JWard, KShen, HWong, HGrossman, SNemeth, GZaczek, RArneric, SPHartig, PRobertson, DWTrainor, G 8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists. J Med Chem52:3073-83 (2009) [PubMed]  Article
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Corticotropin-releasing factor receptor 1
Name:Corticotropin-releasing factor receptor 1
Synonyms:CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:47870.75
Organism:Rattus norvegicus (rat)
Description:Receptor binding assays were performed using rat cortex homogenate.
Residue:415
Sequence:
MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
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BDBM29474
125I-Tyr(0)-ovine-CRF
Name:125I-Tyr(0)-ovine-CRF
Synonyms:Ovine Tyr-CRF | oCRF
Type:radiolabeled substrate
Mol. Mass.:4833.46
Organism:Ovis aries (sheep)
Description:n/a
Residue:42
Sequence:
YSQE PPISLDLTFH LLREVLEMTK ADQLAQQAHS NRKLLDIA
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