Reaction Details |
| Report a problem with these data |
Target | Histone deacetylase |
---|
Ligand | BDBM29593 |
---|
Substrate/Competitor | pfHDAC-1 Substrate |
---|
Meas. Tech. | pfHDAC-1 Enzyme Assay |
---|
pH | 7.5±n/a |
---|
Temperature | 296.15±n/a K |
---|
IC50 | 20±2 nM |
---|
Km | 30000±2000 nM |
---|
kcat | 0.19±0.01 1/sec |
---|
Citation | Patel, V; Mazitschek, R; Coleman, B; Nguyen, C; Urgaonkar, S; Cortese, J; Barker, RH; Greenberg, E; Tang, W; Bradner, JE; Schreiber, SL; Duraisingh, MT; Wirth, DF; Clardy, J Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem52:2185-7 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
Histone deacetylase |
---|
Name: | Histone deacetylase |
Synonyms: | Histone Deacetylase (pfHDAC-1) |
Type: | Enzyme |
Mol. Mass.: | 51371.91 |
Organism: | Plasmodium falciparum (isolate 3D7) |
Description: | Assays were performed using recombinant pfHDAC-1 expressed and purified from S2 insect cells. |
Residue: | 449 |
Sequence: | MSNRKKVAYFHDPDIGSYYYGAGHPMKPQRIRMTHSLIVSYNLYKYMEVYRPHKSDVNEL
TLFHDYEYIDFLSSISLENYREFTYQLKRFNVGEATDCPVFDGLFQFQQSCAGASIDGAS
KLNHHCADICVNWSGGLHHAKMSEASGFCYINDIVLGILELLKYHARVMYIDIDVHHGDG
VEEAFYVTHRVMTVSFHKFGDYFPGTGDITDVGVNHGKYYSVNVPLNDGMTDDAFVDLFK
VVIDKCVQTYRPGAIIIQCGADSLTGDRLGRFNLTIKGHARCVEHVRSYNIPLLVLGGGG
YTIRNVSRCWAYETGVVLNKHHEMPDQISLNDYYDYYAPDFQLHLQPSNIPNYNSPEHLS
RIKMKIAENLRHIEHAPGVQFSYVPPDFFNSDIDDESDKNQYELKDDSGGGRAPGTRAKE
HSTTHHLRRKNYDDDFFDLSDRDQSIVPY
|
|
|
BDBM29593 |
---|
pfHDAC-1 Substrate |
---|
Name: | pfHDAC-1 Substrate |
Synonyms: | n/a |
Type: | fluorogenic, acetylated peptide |
Mol. Mass.: | 1609.93 |
Organism: | n/a |
Description: | n/a |
Residue: | 15 |
Sequence: | |