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TargetRibosyldihydronicotinamide dehydrogenase [quinone]
LigandBDBM29611
Substrate/CompetitorBDBM29211
Meas. Tech.QR2 Inhibition Assay
pH8±n/a
Temperature298.15±n/a K
IC50 1100±200 nM
Citation Calamini BSantarsiero BDBoutin JAMesecar AD Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J 413:81-91 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Ribosyldihydronicotinamide dehydrogenase [quinone]
Name:Ribosyldihydronicotinamide dehydrogenase [quinone]
Synonyms:Metallothionein-3 | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone]
Type:Protein
Mol. Mass.:25917.25
Organism:Homo sapiens (Human)
Description:P16083
Residue:231
Sequence:
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL
SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV
LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC
GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
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  Blast E-value cutoff:
BDBM29611
BDBM29211
NameBDBM29611
Synonyms:2-Iodomelatonin | CHEMBL289233 | Melatonin,2-Iodo
TypeSmall organic molecule
Emp. Form.C13H15IN2O2
Mol. Mass.358.1749
SMILESCOc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1
Structure
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