| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
|---|
| Ligand | BDBM29833 |
|---|
| Substrate/Competitor | BDBM13739 |
|---|
| Meas. Tech. | 11beta-HSD1 Homogeneous Time-Resolved Fluorescence (HTRF) Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 6±n/a nM |
|---|
| Citation |  Lepifre, F; Christmann-Franck, S; Roche, D; Leriche, C; Carniato, D; Charon, C; Bozec, S; Doare, L; Schmidlin, F; Lecomte, M; Valeur, E Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold. Bioorg Med Chem Lett19:3682-5 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| 11-beta-hydroxysteroid dehydrogenase 1 |
|---|
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
|---|
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32409.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P28845 |
|---|
| Residue: | 292 |
|---|
| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
|
|
|
|---|
| BDBM29833 |
|---|
| BDBM13739 |
|---|
| Name | BDBM29833 |
|---|
| Synonyms: | spiro-carboxamide scaffold, 6 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H24ClNO |
|---|
| Mol. Mass. | 317.853 |
|---|
| SMILES | Clc1ccc(cc1)C1(CC1)C(=O)N1CCC2(C1)CCCCC2 |
|---|
| Structure | 
|
|---|
Search and Browse
