Reaction Details | |||
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Target | Nociceptin receptor | ||
Ligand | BDBM29987 | ||
Substrate/Competitor | BDBM29961 | ||
Meas. Tech. | In Vitro Binding Assay (IC50) and In Vitro Agonism/Antagonism Measurements (EC50/IC50) | ||
pH | 7.4±n/a | ||
Temperature | 310.15±n/a K | ||
IC50 | 2.4±n/a nM | ||
EC50 | 0.72±n/a nM | ||
Citation | Kobayashi, K; Uchiyama, M; Takahashi, H; Kawamoto, H; Ito, S; Yoshizumi, T; Nakashima, H; Kato, T; Shimizu, A; Yamamoto, I; Asai, M; Miyazoe, H; Ohno, A; Hirayama, M; Ozaki, S; Tani, T; Ishii, Y; Tanaka, T; Mochidome, T; Tadano, K; Fukuroda, T; Ohta, H; Okamoto, O 2-Cyclohexylcarbonylbenzimidazoles as potent, orally available and brain-penetrable opioid receptor-like 1 (ORL1) antagonists. Bioorg Med Chem Lett19:3096-9 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Nociceptin receptor | |||
Name: | Nociceptin receptor | ||
Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 40702.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P41146 | ||
Residue: | 370 | ||
Sequence: |
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BDBM29987 | |||
BDBM29961 | |||
Name | BDBM29987 | ||
Synonyms: | benzimidazole analogue, 7e | benzimidazole derivative, 1 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H32ClN5O2S | ||
Mol. Mass. | 466.04 | ||
SMILES | CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)NC(=O)OC)nc2cc1Cl |r,wU:14.15,18.22,wD:14.14,(-10.04,.77,;-8.71,,;-7.38,.77,;-7.38,2.31,;-6.04,3.08,;-4.71,2.31,;-4.71,.77,;-6.04,,;-3.38,3.08,;-2.04,2.31,;-.71,3.08,;.76,2.6,;1.66,3.85,;3.2,3.85,;4.29,2.76,;4.84,4.2,;3.59,1.39,;4.42,.1,;5.96,.17,;6.66,1.54,;5.83,2.84,;6.79,-1.12,;8.33,-1.05,;9.04,.32,;9.17,-2.34,;10.71,-2.26,;.76,5.1,;-.71,4.62,;-2.04,5.39,;-3.38,4.62,;-4.71,5.39,)| | ||
Structure |