| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM30126 |
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| Substrate/Competitor | BDBM22166 |
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| Meas. Tech. | Radioligand Binding Assay (Ki) and Inhibition of Substrate Uptake (EC50/IC50) |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | >100000±n/a nM |
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| EC50 | >100000±n/a nM |
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| Citation |  Cashman, JR; Voelker, T; Zhang, HT; O'Donnell, JM Dual inhibitors of phosphodiesterase-4 and serotonin reuptake. J Med Chem52:1530-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 68497.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q01959 |
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| Residue: | 620 |
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| Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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| BDBM30126 |
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| BDBM22166 |
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| Name | BDBM30126 |
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| Synonyms: | CHEMBL313041 | phthalazinone, 19 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N2O3 |
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| Mol. Mass. | 286.3257 |
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| SMILES | COc1ccc(cc1OC)C1=NNC(=O)C2CC=CCC12 |c:18,t:11| |
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| Structure | 
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