Reaction Details |
| Report a problem with these data |
Target | Sodium-dependent serotonin transporter |
---|
Ligand | BDBM30126 |
---|
Substrate/Competitor | BDBM22166 |
---|
Meas. Tech. | Radioligand Binding Assay (Ki) and Inhibition of Substrate Uptake (EC50/IC50) |
---|
pH | 7.4±n/a |
---|
Temperature | 295.15±n/a K |
---|
Ki | >100000±n/a nM |
---|
EC50 | >100000±n/a nM |
---|
Citation | Cashman, JR; Voelker, T; Zhang, HT; O'Donnell, JM Dual inhibitors of phosphodiesterase-4 and serotonin reuptake. J Med Chem52:1530-9 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
Sodium-dependent serotonin transporter |
---|
Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70322.51 |
Organism: | Homo sapiens (Human) |
Description: | P31645 |
Residue: | 630 |
Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
|
|
|
BDBM30126 |
---|
BDBM22166 |
---|
Name | BDBM30126 |
Synonyms: | CHEMBL313041 | phthalazinone, 19 |
Type | Small organic molecule |
Emp. Form. | C16H18N2O3 |
Mol. Mass. | 286.3257 |
SMILES | COc1ccc(cc1OC)C1=NNC(=O)C2CC=CCC12 |c:18,t:11| |
Structure |
|