| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
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| Ligand | BDBM30133 |
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| Substrate/Competitor | BDBM22166 |
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| Meas. Tech. | PDE4 Enzyme Assay |
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| Ki | 19332±n/a nM |
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| EC50 | 20370±n/a nM |
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| Citation |  Cashman, JR; Voelker, T; Zhang, HT; O'Donnell, JM Dual inhibitors of phosphodiesterase-4 and serotonin reuptake. J Med Chem52:1530-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Sodium-dependent noradrenaline transporter |
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| Name: | Sodium-dependent noradrenaline transporter |
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| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 69337.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23975 |
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| Residue: | 617 |
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| Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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| BDBM30133 |
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| BDBM22166 |
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| Name | BDBM30133 |
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| Synonyms: | tetrahydrofuranyl ethylamine, 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H24FNO2 |
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| Mol. Mass. | 281.3657 |
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| SMILES | CNCCC1CCC(CCc2cc(F)ccc2OC)O1 |
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| Structure | 
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