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TargetMAP kinase-activated protein kinase 3
LigandBDBM30185
Substrate/CompetitorHSP27 Peptide
Meas. Tech.Kinase Selectivity Assay
pH7.5±n/a
Temperature303.15±n/a K
IC50 210±n/a nM
Citation Anderson, DR; Meyers, MJ; Vernier, WF; Mahoney, MW; Kurumbail, RG; Caspers, N; Poda, GI; Schindler, JF; Reitz, DB; Mourey, RJ Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem50:2647-54 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
MAP kinase-activated protein kinase 3
Name:MAP kinase-activated protein kinase 3
Synonyms:3pK | Chromosome 3p kinase | MAP kinase-activated protein kinase 3 (MAPKAP-K3) | MAPK-Activated Protein Kinase 3 (MK3) | MAPK-activated protein kinase 3 | MAPK3_HUMAN | MAPKAP kinase 3 | MAPKAPK-3 | MAPKAPK3
Type:Serine/threonine-protein kinase
Mol. Mass.:42991.57
Organism:Homo sapiens (Human)
Description:Recombinant MAPKAPK3 was phosphorylated by incubation with active p38alpha before assays.
Residue:382
Sequence:
MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
LLNKRRKKQAGSSSASQGCNNQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM30185
HSP27 Peptide
Name:HSP27 Peptide
Synonyms:n/a
Type:Peptide
Mol. Mass.:1389.69
Organism:n/a
Description:n/a
Residue:13
Sequence:
KKKALSRNLSVAA