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TargetCollagenase
LigandBDBM30360
Substrate/CompetitorMMP-13 Substrate
Meas. Tech.Determination of MMP-13 Activity
pH7.5±n/a
Temperature295.15±n/a K
IC50 0.5±n/a nM
Citation Monovich LGTommasi RAFujimoto RABlancuzzi VClark KCornell WDDoti RDoughty JFang JFarley DFitt JGanu VGoldberg RGoldstein RLavoie SKulathila RMacchia WParker DTMelton RO'Byrne EPastor GPellas TQuadros EReel NRoland DMSakane YSingh HSkiles JSomers JToscano KWigg AZhou SZhu LShieh WCXue SMcQuire LW Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13. J Med Chem 52:3523-38 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Collagenase
Name:Matrix metalloproteinase (1 and 13)
Synonyms:Collagenase 3 | MMP-13 | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:Enzyme
Mol. Mass.:53808.06
Organism:Homo sapiens (Human)
Description:n/a
Residue:471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM30360
MMP-13 Substrate
Name:MMP-13 Substrate
Synonyms:n/a
Type:Fluorogenic Substrate
Mol. Mass.:2571.45
Organism:n/a
Description:n/a
Residue:24
Sequence:
MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-CONH2