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TargetCollagenase 3
LigandBDBM30366
Substrate/CompetitorMMP-13 Substrate
Meas. Tech.Determination of MMP-13 Activity
pH7.5±n/a
Temperature295.15±n/a K
IC50 3.3±n/a nM
Citation Monovich, LGTommasi, RAFujimoto, RABlancuzzi, VClark, KCornell, WDDoti, RDoughty, JFang, JFarley, DFitt, JGanu, VGoldberg, RGoldstein, RLavoie, SKulathila, RMacchia, WParker, DTMelton, RO'Byrne, EPastor, GPellas, TQuadros, EReel, NRoland, DMSakane, YSingh, HSkiles, JSomers, JToscano, KWigg, AZhou, SZhu, LShieh, WCXue, SMcQuire, LW Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13. J Med Chem52:3523-38 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Collagenase 3
Name:Collagenase 3
Synonyms:MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:Enzyme
Mol. Mass.:53808.06
Organism:Homo sapiens (Human)
Description:P45452
Residue:471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM30366
MMP-13 Substrate
Name:MMP-13 Substrate
Synonyms:n/a
Type:Fluorogenic Substrate
Mol. Mass.:2571.45
Organism:n/a
Description:n/a
Residue:24
Sequence:
MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-CONH2