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TargetStromelysin-1
LigandBDBM30344
Substrate/CompetitorNFF-2 Substrate
Meas. Tech.Determination of MMP-13 Activity
Temperature298.15±n/a K
IC50 87±n/a nM
Commentsextracted
Citation Monovich LGTommasi RAFujimoto RABlancuzzi VClark KCornell WDDoti RDoughty JFang JFarley DFitt JGanu VGoldberg RGoldstein RLavoie SKulathila RMacchia WParker DTMelton RO'Byrne EPastor GPellas TQuadros EReel NRoland DMSakane YSingh HSkiles JSomers JToscano KWigg AZhou SZhu LShieh WCXue SMcQuire LW Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13. J Med Chem 52:3523-38 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Stromelysin-1
Name:Matrix metalloproteinase (2 and 3)
Synonyms:MMP-3 | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | Stromelysin 1 | Transin-1
Type:Enzyme
Mol. Mass.:53973.13
Organism:Homo sapiens (Human)
Description:
Residue:477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM30344
NFF-2 Substrate
Name:NFF-2 Substrate
Synonyms:n/a
Type:Fluorogenic Substrate
Mol. Mass.:2346.23
Organism:n/a
Description:n/a
Residue:20
Sequence:
Mca-RPKPYA-Nva-WM-K(Dnp)-NH2