| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [588-1147,M628L,N654N,K657R,T802F,K807E] |
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| Ligand | BDBM77145 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PHENOSENSE assay |
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| IC50 | 6515±0.0 nM |
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| Citation |  Lanier, ER Methods of treating retroviral infections and related dosage regimes US Patent US9694024 Publication Date 7/4/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Gag-Pol polyprotein [588-1147,M628L,N654N,K657R,T802F,K807E] |
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| Name: | Gag-Pol polyprotein [588-1147,M628L,N654N,K657R,T802F,K807E] |
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| Synonyms: | HIV RT (41L/67N/70R/215F/219E) | POL_HV1H2 | gag-pol |
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| Type: | n/a |
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| Mol. Mass.: | 64541.40 |
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| Organism: | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) |
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| Description: | P04585[588-1147,M628L,N654N,K657R,T802F,K807E] |
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| Residue: | 560 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPDEKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
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| BDBM77145 |
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| n/a |
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| Name | BDBM77145 |
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| Synonyms: | 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine | PMPA prodrug | Tenofovir | Tenofovir disoproxil |
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| Type | Small organic molecule |
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| Emp. Form. | C19H30N5O10P |
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| Mol. Mass. | 519.4428 |
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| SMILES | CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C |
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| Structure | 
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