Reaction Details |
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Target | Gag-Pol polyprotein [588-1147,V662I,F664L,F703Y,Q738M,M771V] |
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Ligand | BDBM77145 |
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Substrate/Competitor | n/a |
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Meas. Tech. | PHENOSENSE assay |
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IC50 | >6494±0.0 nM |
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Citation | Lanier, ER Methods of treating retroviral infections and related dosage regimes US Patent US9694024 Publication Date 7/4/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [588-1147,V662I,F664L,F703Y,Q738M,M771V] |
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Name: | Gag-Pol polyprotein [588-1147,V662I,F664L,F703Y,Q738M,M771V] |
Synonyms: | HIV RT (75I/77L/116Y/151M/184V) | POL_HV1H2 | gag-pol |
Type: | n/a |
Mol. Mass.: | 64453.42 |
Organism: | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) |
Description: | P04585[588-1147,V662I,F664L,F703Y,Q738M,M771V] |
Residue: | 560 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
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BDBM77145 |
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n/a |
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Name | BDBM77145 |
Synonyms: | 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine | PMPA prodrug | Tenofovir | Tenofovir disoproxil |
Type | Small organic molecule |
Emp. Form. | C19H30N5O10P |
Mol. Mass. | 519.4428 |
SMILES | CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C |
Structure |
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