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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | D-amino-acid oxidase | ||
| Ligand | BDBM31152 | ||
| Substrate/Competitor | BDBM23167 | ||
| Meas. Tech. | DAAO in Vitro Activity Assay | ||
| pH | 8.5±n/a | ||
| Temperature | 295.15±n/a K | ||
| IC50 | 8±n/a nM | ||
| Citation |  Duplantier AJ; Becker SL; Bohanon MJ; Borzilleri KA; Chrunyk BA; Downs JT; Hu LY; El-Kattan A; James LC; Liu S; Lu J; Maklad N; Mansour MN; Mente S; Piotrowski MA; Sakya SM; Sheehan S; Steyn SJ; Strick CA; Williams VA; Zhang L Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. J Med Chem 52:3576-85 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method | ||
| D-amino-acid oxidase | |||
| Name: | D-amino-acid oxidase | ||
| Synonyms: | D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | ||
| Type: | Homodimer | ||
| Mol. Mass.: | 39476.06 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 347 | ||
| Sequence: |
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| BDBM31152 | |||
| BDBM23167 | |||
| Name | BDBM31152 | ||
| Synonyms: | 3-hydroxyquinolin-2(1H)-one, 6 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C9H6FNO2 | ||
| Mol. Mass. | 179.1478 | ||
| SMILES | Oc1cc2c(F)cccc2[nH]c1=O | ||
| Structure | 
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