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TargetD-amino-acid oxidase
LigandBDBM31154
Substrate/CompetitorBDBM23167
Meas. Tech.DAAO in Vitro Activity Assay
pH8.5±n/a
Temperature295.15±n/a K
IC50 100±n/a nM
Citation Duplantier, AJBecker, SLBohanon, MJBorzilleri, KAChrunyk, BADowns, JTHu, LYEl-Kattan, AJames, LCLiu, SLu, JMaklad, NMansour, MNMente, SPiotrowski, MASakya, SMSheehan, SSteyn, SJStrick, CAWilliams, VAZhang, L Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. J Med Chem52:3576-85 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
D-amino-acid oxidase
Name:D-amino-acid oxidase
Synonyms:D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:Homodimer
Mol. Mass.:39476.06
Organism:Homo sapiens (Human)
Description:P14920
Residue:347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPN
NPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPR
ELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVN
CTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGG
IFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGP
SNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
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BDBM31154
BDBM23167
NameBDBM31154
Synonyms:3-hydroxyquinolin-2(1H)-one, 8
TypeSmall organic molecule
Emp. Form.C9H6ClNO2
Mol. Mass.195.602
SMILESOc1cc2ccc(Cl)cc2[nH]c1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: