| Reaction Details |
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 | Report a problem with these data |
| Target | D-aspartate oxidase |
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| Ligand | BDBM31157 |
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| Substrate/Competitor | BDBM31174 |
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| Meas. Tech. | DAAO in Vitro Activity Assay |
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| IC50 | 31600±n/a nM |
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| Citation |  Duplantier, AJ; Becker, SL; Bohanon, MJ; Borzilleri, KA; Chrunyk, BA; Downs, JT; Hu, LY; El-Kattan, A; James, LC; Liu, S; Lu, J; Maklad, N; Mansour, MN; Mente, S; Piotrowski, MA; Sakya, SM; Sheehan, S; Steyn, SJ; Strick, CA; Williams, VA; Zhang, L Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. J Med Chem52:3576-85 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| D-aspartate oxidase |
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| Name: | D-aspartate oxidase |
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| Synonyms: | D-Aspartate Oxidase (DDO) | DASOX | DDO | OXDD_HUMAN |
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| Type: | Oxidoreductase |
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| Mol. Mass.: | 37543.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DDO expressed and purified from sf9 insect cells, was used in enzyme assays. |
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| Residue: | 341 |
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| Sequence: | MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTP
IHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMT
EAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVV
NCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKG
DWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPV
VHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL
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| BDBM31157 |
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| BDBM31174 |
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| Name | BDBM31157 |
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| Synonyms: | 3-hydroxyquinolin-2(1H)-one, 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H9NO2 |
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| Mol. Mass. | 175.184 |
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| SMILES | Cc1cccc2cc(O)c(=O)[nH]c12 |
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| Structure | 
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