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TargetD-aspartate oxidase
LigandBDBM31161
Substrate/CompetitorBDBM31174
Meas. Tech.DAAO in Vitro Activity Assay
IC50 61900±n/a nM
Citation Duplantier, AJBecker, SLBohanon, MJBorzilleri, KAChrunyk, BADowns, JTHu, LYEl-Kattan, AJames, LCLiu, SLu, JMaklad, NMansour, MNMente, SPiotrowski, MASakya, SMSheehan, SSteyn, SJStrick, CAWilliams, VAZhang, L Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. J Med Chem52:3576-85 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
D-aspartate oxidase
Name:D-aspartate oxidase
Synonyms:D-Aspartate Oxidase (DDO) | DASOX | DDO | OXDD_HUMAN
Type:Oxidoreductase
Mol. Mass.:37543.06
Organism:Homo sapiens (Human)
Description:Recombinant human DDO expressed and purified from sf9 insect cells, was used in enzyme assays.
Residue:341
Sequence:
MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTP
IHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMT
EAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVV
NCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKG
DWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPV
VHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM31161
BDBM31174
NameBDBM31161
Synonyms:3-hydroxyquinolin-2(1H)-one, 15
TypeSmall organic molecule
Emp. Form.C11H11NO2
Mol. Mass.189.2105
SMILESCCc1cccc2[nH]c(=O)c(O)cc12
Structure
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