Reaction Details |
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Target | D-aspartate oxidase |
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Ligand | BDBM31169 |
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Substrate/Competitor | BDBM31174 |
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Meas. Tech. | DAAO in Vitro Activity Assay |
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IC50 | 32300±n/a nM |
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Citation | Duplantier, AJ; Becker, SL; Bohanon, MJ; Borzilleri, KA; Chrunyk, BA; Downs, JT; Hu, LY; El-Kattan, A; James, LC; Liu, S; Lu, J; Maklad, N; Mansour, MN; Mente, S; Piotrowski, MA; Sakya, SM; Sheehan, S; Steyn, SJ; Strick, CA; Williams, VA; Zhang, L Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. J Med Chem52:3576-85 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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D-aspartate oxidase |
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Name: | D-aspartate oxidase |
Synonyms: | D-Aspartate Oxidase (DDO) | DASOX | DDO | OXDD_HUMAN |
Type: | Oxidoreductase |
Mol. Mass.: | 37543.06 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DDO expressed and purified from sf9 insect cells, was used in enzyme assays. |
Residue: | 341 |
Sequence: | MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTP
IHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMT
EAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVV
NCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKG
DWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPV
VHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL
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BDBM31169 |
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BDBM31174 |
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Name | BDBM31169 |
Synonyms: | 3-hydroxyquinolin-2(1H)-one, 23 | US9701638, 14 |
Type | Small organic molecule |
Emp. Form. | C10H9NO2 |
Mol. Mass. | 175.184 |
SMILES | Cc1c(O)c(=O)[nH]c2ccccc12 |
Structure |
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