| Reaction Details |
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 | Report a problem with these data |
| Target | D-amino-acid oxidase |
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| Ligand | BDBM31150 |
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| Substrate/Competitor | BDBM23167 |
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| Meas. Tech. | DAAO in Vitro Activity Assay |
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| IC50 | 1445±n/a nM |
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| Citation |  Duplantier, AJ; Becker, SL; Bohanon, MJ; Borzilleri, KA; Chrunyk, BA; Downs, JT; Hu, LY; El-Kattan, A; James, LC; Liu, S; Lu, J; Maklad, N; Mansour, MN; Mente, S; Piotrowski, MA; Sakya, SM; Sheehan, S; Steyn, SJ; Strick, CA; Williams, VA; Zhang, L Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. J Med Chem52:3576-85 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| D-amino-acid oxidase |
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| Name: | D-amino-acid oxidase |
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| Synonyms: | D-Amino Acid Oxidase (DAAO) | DAMOX | Dao | Dao1 | OXDA_RAT |
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| Type: | Homodimer |
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| Mol. Mass.: | 38824.91 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Recombinant rat DAAO expressed and purified from sf9 insect cells, was used in enzyme assays. |
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| Residue: | 346 |
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| Sequence: | MRVAVIGAGVIGLSTALCIHERYHPAQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSN
PQEAEWNQQTFDHLQSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKSTVLGFRKLTPSE
LDMFPDYSYGWFNTSLLLEGKSYLSWLTERLTERGVKFIHRKVASFEEVVRGGVDVIINC
TGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGV
FQLGNWSELNSVHDHNTIWKSCCQLEPTLKNARIMGELTGFRPVRPQVRLERERLRFGSS
SAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKNLSRMPPSHL
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| BDBM31150 |
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| BDBM23167 |
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| Name | BDBM31150 |
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| Synonyms: | 3-hydroxyquinolin-2(1H)-one, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H6FNO2 |
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| Mol. Mass. | 179.1478 |
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| SMILES | Oc1cc2ccc(F)cc2[nH]c1=O |
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| Structure | 
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