| Reaction Details |
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 | Report a problem with these data |
| Target | Dimer of Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM718 |
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| Substrate/Competitor | HIV-1 Protease substrate |
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| Meas. Tech. | Protease Inhibition Assay |
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| pH | 6±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 0.16±n/a nM |
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| Citation |  Mimoto, T; Kato, R; Takaku, H; Nojima, S; Terashima, K; Misawa, S; Fukazawa, T; Ueno, T; Sato, H; Shintani, M; Kiso, Y; Hayashi, H Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine. J Med Chem42:1789-802 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| |
| Dimer of Gag-Pol polyprotein [489-587] |
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| Name: | Dimer of Gag-Pol polyprotein [489-587] |
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| Synonyms: | HIV-1 Protease |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10822.21 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P12497[489-587] |
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| Residue: | 99 |
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| Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
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| Component 2 |
| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10822.21 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P12497[489-587] |
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| Residue: | 99 |
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| Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
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| BDBM718 |
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| HIV-1 Protease substrate |
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| Name: | HIV-1 Protease substrate |
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| Synonyms: | n/a |
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| Type: | Peptide |
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| Mol. Mass.: | 2535.82 |
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| Organism: | Synthetic peptide |
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| Description: | n/a |
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| Residue: | 22 |
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| Sequence: | H-Ser-Gln-Asn-Tyr-Pro-Ile-Val-OH
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