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Reaction Details
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TargetHIV-1 Protease
LigandBDBM724
Substrate/CompetitorPeptide substrate
Meas. Tech.Protease Inhibition Assay
pH5.5±n/a
Temperature303.15±n/a K
IC50 0.03±n/a nM
Citation Smith ABCantin LDPasternak AGuise-Zawacki LYao WCharnley AKBarbosa JSprengeler PAHirschmann RMunshi SOlsen DBSchleif WAKuo LC Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors. J Med Chem 46:1831-44 (2003) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
HIV-1 Protease
Name:HIV-1 Protease
Synonyms:HIV-1 Protease, recombinant, isolate HXB2
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:HIV-1 Protease chain A
Synonyms:BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | LAI(Wild type) | Protease Retropepsin
Type:Enzyme Subunit
Mol. Mass.:10795.19
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:HIV-1 Protease chain A
Synonyms:BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | LAI(Wild type) | Protease Retropepsin
Type:Enzyme Subunit
Mol. Mass.:10795.19
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM724
Peptide substrate
Name:Peptide substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:755.86
Organism:n/a
Description:n/a
Residue:7
Sequence:
VSQNXPIV