Reaction Details |
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Target | Dimer of Gag-Pol polyprotein [501-599] |
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Ligand | BDBM727 |
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Substrate/Competitor | Peptide substrate |
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Meas. Tech. | Protease Inhibition Assay |
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pH | 5.5±n/a |
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Temperature | 303.15±n/a K |
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IC50 | 2.0±n/a nM |
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Citation | Smith, AB; Cantin, LD; Pasternak, A; Guise-Zawacki, L; Yao, W; Charnley, AK; Barbosa, J; Sprengeler, PA; Hirschmann, R; Munshi, S; Olsen, DB; Schleif, WA; Kuo, LC Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors. J Med Chem46:1831-44 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Dimer of Gag-Pol polyprotein [501-599] |
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Name: | Dimer of Gag-Pol polyprotein [501-599] |
Synonyms: | HIV-1 Protease | HIV-1 Protease, recombinant, isolate HXB2 |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [501-599] |
Synonyms: | BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | HIV-1 Protease chain A | LAI(Wild type) | POL_HV1BR | Protease Retropepsin | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10795.19 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P03367[501-599] |
Residue: | 99 |
Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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Component 2 |
Name: | Gag-Pol polyprotein [501-599] |
Synonyms: | BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | HIV-1 Protease chain A | LAI(Wild type) | POL_HV1BR | Protease Retropepsin | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10795.19 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P03367[501-599] |
Residue: | 99 |
Sequence: | PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM727 |
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Peptide substrate |
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Name: | Peptide substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 755.86 |
Organism: | n/a |
Description: | n/a |
Residue: | 7 |
Sequence: | |