| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Heme oxygenase 2 |
|---|
| Ligand | BDBM31673 |
|---|
| Substrate/Competitor | methemalbumin |
|---|
| Meas. Tech. | In Vitro HO Activity Assay |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 500±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Vlahakis, JZ; Hum, M; Rahman, MN; Jia, Z; Nakatsu, K; Szarek, WA Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring. Bioorg Med Chem17:2461-75 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Heme oxygenase 2 |
|---|
| Name: | Heme oxygenase 2 |
|---|
| Synonyms: | HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 35754.99 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | HO-2 obtained from rat brain was used in enzyme assays. |
|---|
| Residue: | 315 |
|---|
| Sequence: | MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGN
IKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENW
EEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTG
EGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAG
SMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILA
ASVALVAGLLAWYYM
|
|
|
|---|
| BDBM31673 |
|---|
| methemalbumin |
|---|
| Name: | methemalbumin |
|---|
| Synonyms: | ALB | ALBU_HUMAN | heme complexed with albumin |
|---|
| Type: | albumin complex |
|---|
| Mol. Mass.: | 66464.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Sequence of human serum albumin is shown here. |
|---|
| Residue: | 585 |
|---|
| Sequence: | DAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAE
NCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEV
DVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLP
KLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTK
VHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPA
DLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKC
CAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVST
PTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTES
LVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKAT
KEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL
|
|
|
|---|
Search and Browse
