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TargetCytochrome P450 3A1
LigandBDBM31664
Substrate/Competitorerythromycin
IC50 2800±n/a nM
Citation Vlahakis, JZHum, MRahman, MNJia, ZNakatsu, KSzarek, WA Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring. Bioorg Med Chem17:2461-75 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cytochrome P450 3A1
Name:Cytochrome P450 3A1
Synonyms:CP3A1_RAT | CYPIIIA1 | Cyp3a-1 | Cyp3a1 | P450-PCN1
Type:Enzyme
Mol. Mass.:57928.74
Organism:Rattus norvegicus (rat)
Description:CYP3A1/3A2 prepared from rat liver microsomes was used in enzyme assays.
Residue:504
Sequence:
MDLLSALTLETWVLLAVVLVLLYGFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYMGLWKF
DVECHKKYGKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPVGIMGKAVSV
AKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQEAETGKPVTMKKVFGAYS
MDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICM
FPKDSIEFFKKFVYRMKETRLDSVQKHRVDFLQLMMNAHNDSKDKESHTALSDMEITAQS
IIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMV
LNETLRLYPIGNRLERVCKKDVEINGVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPERF
SKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKLSR
QGLLQPTKPIILKVVPRDEIITGS
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  Blast E-value cutoff:
BDBM31664
erythromycin
NameBDBM31664
Synonyms:imidazole-dioxolane, 16
TypeSmall organic molecule
Emp. Form.C22H29ClN2O2S
Mol. Mass.420.996
SMILESClc1ccc(CC[C@@]2(Cn3ccnc3)OC[C@@H](CSC3CCCCC3)O2)cc1 |r|
Structure
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