| Reaction Details |
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 | Report a problem with these data |
| Target | Heme oxygenase 2 |
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| Ligand | BDBM31769 |
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| Substrate/Competitor | methemalbumin |
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| Meas. Tech. | In Vitro HO Activity Assay |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 5000±3000 nM |
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| Citation |  Kinobe, RT; Dercho, RA; Vlahakis, JZ; Brien, JF; Szarek, WA; Nakatsu, K Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. J Pharmacol Exp Ther319:277-84 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Heme oxygenase 2 |
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| Name: | Heme oxygenase 2 |
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| Synonyms: | HMOX2_RAT | Heme Oxygenase 2 (HO-2) | Heme oxygenase 2 | Hmox2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 35754.99 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | HO-2 obtained from rat brain was used in enzyme assays. |
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| Residue: | 315 |
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| Sequence: | MSSEVETSEGVDESENNSTAPEKENHTKMADLSELLKEGTKEAHDRAENTQFVKDFLKGN
IKKELFKLATTALYFTYSALEEEMDRNKDHPAFAPLYFPTELHRKEALIKDMEYFFGENW
EEQVKCSEAAQKYVDRIHYVGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPSTG
EGTQFYLFEHVDNAQQFKQFYRARMNALDLSMKTKERIVEEANKAFEYNMQIFSELDQAG
SMLTKETLEDGLPVHDGKGDVRKCPFYAAQPDKGTLGGSNCPFRTAMAVLRKPSLQLILA
ASVALVAGLLAWYYM
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| BDBM31769 |
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| methemalbumin |
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| Name: | methemalbumin |
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| Synonyms: | ALB | ALBU_HUMAN | heme complexed with albumin |
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| Type: | albumin complex |
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| Mol. Mass.: | 66464.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Sequence of human serum albumin is shown here. |
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| Residue: | 585 |
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| Sequence: | DAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAE
NCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEV
DVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLP
KLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTK
VHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPA
DLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKC
CAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVST
PTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTES
LVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKAT
KEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL
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