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TargetThymidylate synthase
LigandBDBM31781
Substrate/CompetitorBDBM18754
Meas. Tech.Thymidylate Synthase (TS) Assay
pH7.4±n/a
Temperature303.15±n/a K
IC50>23000±n/a nM
Citation Gangjee, ALi, WKisliuk, RLCody, VPace, JPiraino, JMakin, J Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. J Med Chem52:4892-902 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Thymidylate synthase
Name:Thymidylate synthase
Synonyms:TS | TSase | TYSY_ECOLI | Thymidylate Synthase (TS) | thyA
Type:Enzyme
Mol. Mass.:30475.81
Organism:Escherichia coli
Description:n/a
Residue:264
Sequence:
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL
WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK
NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS
YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF
DYRFEDFEIEGYDPHPGIKAPVAI
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BDBM31781
BDBM18754
NameBDBM31781
Synonyms:thieno[2,3-d]pyrimidine deriv., 2d
TypeSmall organic molecule
Emp. Form.C16H17N3O3S2
Mol. Mass.363.454
SMILESCCc1sc2nc(N)[nH]c(=O)c2c1Sc1cc(OC)ccc1OC
Structure
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