| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
|---|
| Ligand | BDBM31830 |
|---|
| Substrate/Competitor | biotinylated poly-Glu-Tyr |
|---|
| Meas. Tech. | Kinetics Assay for IC50 Determination |
|---|
| pH | 7±n/a |
|---|
| Temperature | 296.15±n/a K |
|---|
| IC50 | 207±79 nM |
|---|
| Kd | 256±64 nM |
|---|
| Citation |  Getlik, M; Grütter, C; Simard, JR; Klüter, S; Rabiller, M; Rode, HB; Robubi, A; Rauh, D Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc. J Med Chem52:3915-26 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Proto-oncogene tyrosine-protein kinase Src |
|---|
| Name: | Proto-oncogene tyrosine-protein kinase Src |
|---|
| Synonyms: | Proto-oncogene c-Src | SRC | SRC_CHICK | Tyrosine-protein kinase SRC | c-Src | p60-Src | p60c-src | pp60c-src |
|---|
| Type: | Tyr protein kinase |
|---|
| Mol. Mass.: | 60015.36 |
|---|
| Organism: | Gallus gallus (Chicken) |
|---|
| Description: | P00523 |
|---|
| Residue: | 533 |
|---|
| Sequence: | MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKL
FGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWL
AHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETT
KGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHR
LTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG
TMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRL
PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ
GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR
MPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
|
|
|
|---|
| BDBM31830 |
|---|
| biotinylated poly-Glu-Tyr |
|---|
| Name: | biotinylated poly-Glu-Tyr |
|---|
| Synonyms: | n/a |
|---|
| Type: | Peptide |
|---|
| Mol. Mass.: | 358.43 |
|---|
| Organism: | n/a |
|---|
| Description: | n/a |
|---|
| Residue: | 3 |
|---|
| Sequence: | |
|---|
Search and Browse
