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TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M]
LigandBDBM13216
Substrate/Competitorbiotinylated poly-Glu-Tyr
Meas. Tech.Kinetics Assay for IC50 Determination
pH7±n/a
Temperature296.15±n/a K
IC50 480±400 nM
Citation Getlik, M; Grütter, C; Simard, JR; Klüter, S; Rabiller, M; Rode, HB; Robubi, A; Rauh, D Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc. J Med Chem52:3915-26 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Proto-oncogene tyrosine-protein kinase Src [251-533,T338M]
Name:Proto-oncogene tyrosine-protein kinase Src [251-533,T338M]
Synonyms:Proto-oncogene tyrosine-protein kinase Src | SRC | SRC_CHICK | Src Mutant (T338M)
Type:Tyr protein kinase
Mol. Mass.:32390.51
Organism:Gallus gallus (Chicken)
Description:Mutation of T338M was introduced by site-directed mutagenesis and confirmed by sequence analysis.
Residue:283
Sequence:
QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQE
AQVMKKLRHEKLVQLYAVVSEEPIYIVMEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQI
ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA
PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES
LHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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  Blast E-value cutoff:
BDBM13216
biotinylated poly-Glu-Tyr
Name:biotinylated poly-Glu-Tyr
Synonyms:n/a
Type:Peptide
Mol. Mass.:358.43
Organism:n/a
Description:n/a
Residue:3
Sequence:
n/a