Reaction Details |
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Target | Epidermal growth factor receptor [668-1210] |
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Ligand | BDBM31826 |
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Substrate/Competitor | Tyr 04 Substrate Peptide |
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Meas. Tech. | EGFR IC50 Determination |
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pH | 7.5±n/a |
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Temperature | 296.15±n/a K |
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IC50 | 0.43±n/a nM |
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Citation | Michalczyk, A; Klüter, S; Rode, HB; Simard, JR; Grütter, C; Rabiller, M; Rauh, D Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg Med Chem16:3482-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Epidermal growth factor receptor [668-1210] |
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Name: | Epidermal growth factor receptor [668-1210] |
Synonyms: | EGF-R Tyrosine Kinase | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR) | HER1 | Receptor tyrosine-protein kinase ErbB-1 |
Type: | Cytoplasmic region |
Mol. Mass.: | 61304.06 |
Organism: | Homo sapiens (Human) |
Description: | Wildtype EGFR was purchased from Invitrogen. |
Residue: | 543 |
Sequence: | MRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVY
KGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ
LITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT
PQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWEL
MTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIE
FSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSP
STSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFL
PVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCV
NSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEF
IGA
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BDBM31826 |
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Tyr 04 Substrate Peptide |
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Name: | Tyr 04 Substrate Peptide |
Synonyms: | n/a |
Type: | FRET-peptide substrate |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | n/a |
Residue: | 3 |
Sequence: | |