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TargetEGF-R Tyrosine Kinase Mutant (T790M)
LigandBDBM4567
Substrate/CompetitorTyr 04 Substrate Peptide
Meas. Tech.EGFR IC50 Determination
pH7.5±n/a
Temperature296.15±n/a K
IC50 1.2±n/a nM
Citation Michalczyk AKlüter SRode HBSimard JRGrütter CRabiller MRauh D Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg Med Chem 16:3482-8 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
EGF-R Tyrosine Kinase Mutant (T790M)
Name:EGF-R Tyrosine Kinase Mutant (T790M)
Synonyms:Receptor tyrosine-protein kinase ErbB-1
Type:Cytoplasmic region
Mol. Mass.:57805.41
Organism:Homo sapiens (Human)
Description:EGFR-T790M was purchased from Upstate.
Residue:515
Sequence:
GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA
NKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLL
NWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGK
VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQ
PPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDS
NFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGL
QSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPL
NPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQD
FFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM4567
Tyr 04 Substrate Peptide
Name:Tyr 04 Substrate Peptide
Synonyms:n/a
Type:FRET-peptide substrate
Mol. Mass.:358.43
Organism:n/a
Description:n/a
Residue:3
Sequence:
n/a