| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [696-1210,T790M] |
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| Ligand | BDBM31826 |
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| Substrate/Competitor | Tyr 04 Substrate Peptide |
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| Meas. Tech. | EGFR IC50 Determination |
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| pH | 7.5±n/a |
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| Temperature | 296.15±n/a K |
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| IC50 | 360±n/a nM |
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| Citation |  Michalczyk, A; Klüter, S; Rode, HB; Simard, JR; Grütter, C; Rabiller, M; Rauh, D Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR. Bioorg Med Chem16:3482-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Epidermal growth factor receptor [696-1210,T790M] |
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| Name: | Epidermal growth factor receptor [696-1210,T790M] |
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| Synonyms: | EGF-R Tyrosine Kinase Mutant (T790M) | EGFR | EGFR_HUMAN | ERBB | ERBB1 | HER1 | Receptor tyrosine-protein kinase ErbB-1 |
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| Type: | Cytoplasmic region |
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| Mol. Mass.: | 57805.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EGFR-T790M was purchased from Upstate. |
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| Residue: | 515 |
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| Sequence: | GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA
NKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLL
NWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGK
VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQ
PPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDS
NFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGL
QSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPL
NPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQD
FFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
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| BDBM31826 |
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| Tyr 04 Substrate Peptide |
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| Name: | Tyr 04 Substrate Peptide |
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| Synonyms: | n/a |
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| Type: | FRET-peptide substrate |
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| Mol. Mass.: | 358.43 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 3 |
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| Sequence: | |
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